The transgene contains the fatty acid binding protein 4 (Fabp4/aP2) promoter driving adipose-specific expression of a cDNA encoding the A isoform of human lamin A with substitution of glutamine for arginine at amino acid position 482 followed by an SV40 splice site and poly(A) signal. This amino acid substitution was identified in patients with familial partial lipodystrophy of the Dunnigan type (FPLD2). A mouse line was generated from founder 11A.