Version: 8.0.0
Date: Tue Jan 28 2025
Tg(AMH-Fshr*D580H)14Hht
MGI:4456199Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(AMH-Fshr*D580H)14Hht

Species
Mus musculus
Symbol
Tg(AMH-Fshr*D580H)14Hht
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • mFshrD580H
  • Tg(AMH-FSHRD580H)
Description
The transgene contains a 3.6 kb human AMH promoter, and a murine Fshr with Asp580His mutation. Line number 14 was used in the study of mRNA and hormone level. mRNA of the transgenes was expressed in the ovaries and testes. The expression level of the transgene was similar to that of the endogenous mFshr in the ovaries. The severity of the abnormalities detected in ovaries, adrenal gland, pituitary gland and mammary gland correlated with the ovarian transgenic expression level.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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