Cbfb^tm3Ppl

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Species

Mus musculus

Symbol

Cbfb^tm3Ppl

Category

allele

Allele of gene

Cbfb

Transgenic Constructs

None

Synonyms

• Cbfb^MYH11 (d179-221)

Description

Exon 5 was replaced by a construct composed of the first 25 bp of mouse exon 5 fused to the 3' end of a human CBFB/MYH11 cDNA. The human cDNA fragment used contained the last 66 bp of human exon 5 and exons 33-42 of MYH11. The sequence in exon 33 encoding amino acids 179-221 are deleted. A bovine growth hormone polyadenylation site and a floxed PGK-neomycin cassette were inserted immediately downstream.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations