Allele/Variant

S1pr1tm1.1Thla

Species
Mus musculus
Symbol
S1pr1tm1.1Thla
Category
allele
Allele of gene
S1pr1
Transgenic Constructs
None
Synonyms
  • S1p1rS5A
Description
Nucleotide substitutions in exon 2 result in the amino acid substitution of five serines with alanines (p.[Ser351Ala;Ser353Ala;Ser355Ala] and p.(Ser358_Ser359delinsAlaAla)). This prevents phosphorylization of the five residues and the produced protein fails to internalize correctly, but signaling is not disrupted. A loxP site flanked neomycin resistance gene cassette inserted into intron 2 was removed by subsequent cre-mediated recombination.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations