Allele/Variant

Adam17tm1.1Srj

Species
Mus musculus
Symbol
Adam17tm1.1Srj
Category
allele
Allele of gene
Adam17
Transgenic Constructs
None
Synonyms
  • ADAM17ex
Description
An FRT flanked neo with a 5' loxP site was inserted upstream of exon 11. A modified exon 11 (exon 11a) was inserted downstream of the endogenous exon. It contains a stop codon at the 5' end and a loxP site at the 3' end. Flp mediated recombination removed the neo cassette leaving exons 11 and 11a floxed. Severely reduced protein expression was confirmed by western blot analysis on skin and heart extracts. This is a hypomorphic allele.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations