Scn1b^tm1.1Bion

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Species

Mus musculus

Symbol

Scn1b^tm1.1Bion

Category

allele

Allele of gene

Scn1b

Transgenic Constructs

None

Synonyms

• beta1^C121W
• Scn1b^W

Description

Exon 3 was replaced with one in which a C to G transversion (C387G) results in the amino acid substitution of tryptophan for cysteine at position 121 (C121W), mimicking a mutation found in some genetic epilepsy with febrile seizures plus (GEFS+) patients. A loxP was inserted upstream of the modified exon 3. A floxed neo cassette inserted downstream of the modified exon was removed by cre mediated recombination. The modified exon 3 remains floxed.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations