Hprt1^{tm73(Ple142-lacZ)Ems}

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Species

Mus musculus

Symbol

Hprt1^{tm73(Ple142-lacZ)Ems}

Category

allele

Allele of gene

Hprt1

Transgenic Constructs

None

Synonyms

• Hprt^{tm73(mEMS4751)Ems}
• NR2E1-lacZ

Show All 3

Description

The Ple142-lacZ transgene (bEMS86) was designed with the Ple142 MaxiPromoter (NR2E1-X; derived from the BAC RP11-144P8 that contains the whole (NR2E1) gene plus ~42 kb upstream and ~52 kb downstream, and also contains a portion of the SNX3 gene in the downstream sequence from the nuclear receptor subfamily 2, group E, member 1 (NR2E1) gene) upstream of a frt-flanked beta-galactosidase (lacZ) gene, an SV40 early polyA signal, and a human HPRT complementary sequence (containing exon1, intron1, exon2, and part of intron2). This construct was targeted as a single copy knockin to the Hprt^b-m3 mutant locus on the X chromosome.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations