Allele/Variant

Tg(Fev-cre/ERT2)aEsd

Species

Mus musculus

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

ePet::CreER^T2ascend

Description

A 40 kb genomic fragment of Fev enhancer sequence and a beta-globin minimal promoter drive expression a fusion gene of cre and a mutant human estrogen receptor. This transgene also contains beta-globin intron and simian virus 40 polyadenylation sequences. After tamoxifen treatment this line shows recombination in up to 80% of the serotonergic neurons in the dorsal Raphe nucleus (B6, B7) the medial Raphe nucleus (B5, B8) and B9 nucleus. Minimal recombination is seen in the medullary nuclei (B1-B3).

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

None

Knock-down Targets

None

Regulatory Regions

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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Disease Associations

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