App^tm2.1Zhe

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Species

Mus musculus

Symbol

App^tm2.1Zhe

Category

allele

Allele of gene

App

Transgenic Constructs

None

Synonyms

• App sbeta KI

Description

The mutated allele contains a loxP site immediately upstream of an exon 16 sequence modified by the insertion of a FLAG motif and a stop codon just downstream of the beta secretase cleavage site. The mutated copy of exon 16 was separated from a second, intact, copy of exon 16 by a sequence cassette containing two copies of neomycin flanked by FRT sites and followed by a second loxP site. Flp recombinase was then used to excise the two neomycin sequences leaving the mutated exon 16 surrounded by loxP sites. Transmembrane and intracellular sequences are deleted from the translation product.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations