Tbc1d2^{tm1(NCOM)Cmhd}

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Species

Mus musculus

Symbol

Tbc1d2^{tm1(NCOM)Cmhd}

Category

allele

Allele of gene

Tbc1d2

Transgenic Constructs

None

Synonyms

None

Description

The insertion of NorCOMM cassette pNTARU created a deletion of size 381bp between positions 46646016-46646397 of Chromosome 4 (Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an F3 site followed by a universal inverse PCR primer site and a splice acceptor lacZ-neomycin phosphotransferase fusion (beta-geo) sequence. This is followed by a PhiC31 attP site and a puromycin sequence that is not active unless a promoter is inserted by PhiC31 at the attP site. The cassette is finished with an FRT site. Variations of this allele can be made using PhiC31 docking and subsequent cloning (Nagy et al., 2009. Methods Mol. Biol. 530:365-78).

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations