Allele/Variant

Tg(Prnp-TARDBP*A315T)23Jlel

Species
Mus musculus
Symbol
Tg(Prnp-TARDBP*A315T)23Jlel
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • A315T TDP-43 line 23
Description
The mouse promoter drives neuronal expression of the human cDNA with point mutations that result in the amino acid substitution of threonine for alanine at position 315 (A315T). This mutation was identified in human patients with amyotrophic lateral sclerosis with TARDBP proteinopathies. Four lines were established (23, 27, 35, and 61).
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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