Dcaf11^{tm1a(KOMP)Wtsi}

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Species

Mus musculus

Symbol

Dcaf11^{tm1a(KOMP)Wtsi}

Category

allele

Allele of gene

Dcaf11

Transgenic Constructs

None

Synonyms

• Wdr23tm1a

Description

The L1L2_Bact_P cassette was inserted at position 55799862 of Chromosome 14 upstream of the critical exons 3-11 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exons 3-11 at position 55803501. The critical exons 3-11 are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations