Itm2b^tm3.1Ldad

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Species

Mus musculus

Symbol

Itm2b^tm3.1Ldad

Category

allele

Allele of gene

Itm2b

Transgenic Constructs

None

Synonyms

• Bri2^tABri
• FBD^KI

Description

Exon 6 was replaced with one in which nucleotide substitutions result in the introduction of an XbaI site at nucleotide 799 and the amino acid substitution of arginine for a stop codon at position 267 (X267R) recapitulating the familial British dementia (FBD) mutation and alanine for threonine at the 12th codon of exon 6 to humanize the sequence. A neo cassette inserted upstream of the modified exon 6 was removed by cre-mediated recombination.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations