Allele/Variant

Tg(Prnp-ATXN3*79Q)#Hlw

Species

Mus musculus

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

Ataxin-3-Q79

Description

The mouse promoter drive neuronal expression of the HA-tagged human cDNA with a trinucleotide repeat that results in a 79 glutamine stretch. This amplification of the glutamine tract is associated with Spinocerebellar Ataxia 3 (SCA3) in humans. Two lines with more than five copies of the transgene were generated. The pound symbol (#) denotes when no line number is specified and/or lines are pooled.

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

ATXN3 (Hsa)

Knock-down Targets

None

Regulatory Regions

None

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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Disease Associations

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