Grina^tm1.1Ldh

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Species

Mus musculus

Symbol

Grina^tm1.1Ldh

Category

allele

Allele of gene

Grina

Transgenic Constructs

None

Synonyms

None

Description

The 8 Kb targeting vector was designed to replace a region upstream of exon 2 to downstream of exon 8 with EGFP and a loxP-flanked neomycin (neo) resistance cassette (in opposite transcriptional orientation to the EGFP). The vector also changed the initiation codon at the beginning of exon 2. The neomycin cassette was removed by crossing mice with a transgenic strain expressing Tg(Ella-cre)C5379Lgmd. Northern blot confirmed the absence of mRNA. EGFP expression is detected throughout the brain, and is elevated in the hippocampus.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations