Allele/Variant

Tg(Adipoq-icre/ERT2)1Soff

Species
Mus musculus
Symbol
Tg(Adipoq-icre/ERT2)1Soff
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Adipoq creER(T)2
  • AdipoqCreERT2
Description
A targeting vector containing cDNA encoding icre fused to the mutated form of the ligand-binding domain of the human estrogen receptor followed by an Frt-flanked ampicillin resistance marker was generated. Homologous recombination resulted in the insertion of the vector into the start codon of the Adipoq locus present in a BAC clone (RP23-112M7; this BAC also contained the genes Kng1, Eif4a2, and Rfc4.) Flp-mediated excision removed the ampicillin marker. Five founders were obtained and crossed with lacZ reporter mice. Progeny of one founder displayed homogeneous lacZ expression in epididymal, mesenteric, and retroperitoneal white adipose tissue after tamoxifen treatment.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
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