Aldob^{tm1(KOMP)Vlcg}

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Species

Mus musculus

Symbol

Aldob^{tm1(KOMP)Vlcg}

Category

allele

Allele of gene

Aldob

Transgenic Constructs

None

Synonyms

• Aldo2^-

Description

The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 8162bp between positions 49536744-49544905 of Chromosome 4 (Build GRCm39). The cassette replaced 3' of exon 2 through 5' of exon 9. Enzyme activity assays of liver lysates revealed that activity toward fructose 1-phosphate was undetectable, and resulted in a change in the fructose 1,6-bisphosphate:fructose 1-phosphate activity ratio from 1.7 in wild-type mice to over 10 in homozygous mutant mice, indicating that any remaining aldolase activity was due to aldolase A.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations