Allele/Variant

Rbck1tm1Kiwa

Species
Mus musculus
Symbol
Rbck1tm1Kiwa
Category
allele
Allele of gene
Rbck1
Transgenic Constructs
None
Synonyms
  • HOIL-1L-
Description
Exons 7 and 8 were replaced with a neomycin selection cassette. The absence of protein expression was confirmed by western blot analysis on liver extracts using antibody to the C-terminal part of the protein. Subsequent studies showed that an N-terminal portion of the protein containing the UBL domain was still present, possibly the product of a splice variant of the gene not affected by the mutation, or because of incomplete nonsense-mediated mRNA decay (NMD).
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations