Kpna6^tm1Bdr

---

Species

Mus musculus

Symbol

Kpna6^tm1Bdr

Category

allele

Allele of gene

Kpna6

Transgenic Constructs

None

Synonyms

• alpha7^deltaIBB

Description

Exon 2 was replaced with a floxed neo cassette via homologous recombination. An alternatively spliced mRNA encoding for a protein lacking the importin beta-binding domain is produced. Only a truncated non-functional protein is found in homozygous mutant testes and mRNA levels are strongly decreased as transcription from testis-specific exon 1A does not occur.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations