Allele/Variant

Cdk6tm3.1Phin

Species
Mus musculus
Symbol
Cdk6tm3.1Phin
Category
allele
Allele of gene
Cdk6
Transgenic Constructs
None
Synonyms
  • Cdk6K43M
Description
Exon 1 was replaced with one in which nucleotide substitutions result in the amino acid substitution of methionine for lysine at position 43 (K43M). A floxed stop cassette downstream of the modified exon 1 that prevents expression was removed by cre-mediated recombination. The product is predicted to be an inactive kinase.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal hematopoietic stem cell physiologyMGI
abnormal T cell differentiationMGI
enlarged thymusMGI
increased CD4-positive, alpha-beta T cell numberMGI
increased DN1 thymic pro-T cell numberMGI
increased hematopoietic stem cell numberMGI
increased T cell apoptosisMGI
increased thymocyte numberMGI
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Disease Associations

No data available