Allele/Variant

Mdm4tm1Zmy

Species
Mus musculus
Symbol
Mdm4tm1Zmy
Category
allele
Allele of gene
Mdm4
Transgenic Constructs
None
Synonyms
  • MdmxC462A
Description
Exon 12 was replaced with a mutated version where cysteine codon 462 (TGT) was changed to alanine (GCT) (p.C462A) and a neomycin resistance gene cassette was inserted into intron 11. RT-PCR analysis confirmed the expression of the mutant transcript. This mutation interferes with binding to Mdm2. Immunohistochemical analysis indicates protein expression is increased in homozygous embryos compared to heterozygous or wild-type mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
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