Version: 8.0.0
Date: Tue Jan 28 2025
Etv6tm1.1(RUNX1,hsb5)Lvdw
MGI:5284820
Allele of Etv6
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Etv6tm1.1(RUNX1,hsb5)Lvdw

Species
Mus musculus
Symbol
Etv6tm1.1(RUNX1,hsb5)Lvdw
Category
allele
Allele of gene
Etv6
Transgenic Constructs
None
Synonyms
  • Etv6RUNX1
Description
A construct, which contains a lox66, exons 1 through 6 of human RUNX1 (hAML1), IRES, hyperactive variant of sleeping beauty (hsb5), polyadenylation sequence, FRT-flanked puro cassette, and lox71 site, was inserted into intron 5. Mice express a Etv6/RUNX1 fusion to replicate the TEL-AML1 translocation associated with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and hsb5. Flp-mediated recombination removed the puro cassette. Embryonic lethality indicates that no functional endogenous protein is produced despite the production of the endogenous transcript.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
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