Allele/Variant

Nrltm1.1(Thrb)Df

Species
Mus musculus
Symbol
Nrltm1.1(Thrb)Df
Category
allele
Allele of gene
Nrl
Transgenic Constructs
None
Synonyms
  • Nrlb2
Description
The entire coding region was replaced with an in-frame cDNA for mouse Thrb2 and a floxed neo cassette via homologous recombination. Cre mediated recombination removed the neo cassette. Western blot analysis indicated protracted expression of Thrb2 and absence of expression of Nrl in mice at E17.5. In situ hybridization showed ectopic expression of Thrb mRNA over the outer neuroblastic layer of the retina at P7 in homozygous and heterozygous mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations