Syt10^{tm1.1(icre)Geno}

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Species

Mus musculus

Symbol

Syt10^{tm1.1(icre)Geno}

Category

allele

Allele of gene

Syt10

Transgenic Constructs

Synonyms

• Syt10^Cre

Description

A targeting construct containing cre recombinase, an IRES, and cDNA encoding EGFP replaced the Syt10 exon 1 sequence following the initiating ATG codon in ES cells. An Frt-flanked neomycin selection cassette after the EGFP sequence was also included. This was subsequently deleted from F1 animals by crossing to Gt(ROSA)26Sor^tm1(FLP1)Dym mice on a C57BL/6 background. No transcripts of Syt10 are detected in the suprachiasmatic nuclei or other sites of endogenous expression in the brain. Breeding experiments show that cre is active in the male germline.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations