Version: 8.0.0Date: Tue Jan 28 2025
Allele/Variant
Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove
- Species
- Mus musculus
- Symbol
- Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove
- Category
- allele
- Allele of gene
- Spink5
- Transgenic Constructs
- None
- Synonyms
- OVE1498
- Description
- A transposon transgene containing mouse Pgk2 driving expression of sleeping beauty 10 (SB10) and a mouse tyrosinase minigene driven by a Tyr enhancer flanked by Sleeping Beauty inverted repeats (termed pT-Tybs-3'E) were co-injected with a Pgk2 driven SB10. In line 1498, transposon and transposase co-integration results in a 66.8 kb deletion containing the coding exons of the targeted gene and none of the coding regions of the genes flanking the integration site. RT-PCR confirmed the absence of transcript expression at P0 skin cDNA.
- Additional Information
- Literature