Allele/Variant

Bcl2tm2.1Lbox

Species
Mus musculus
Symbol
Bcl2tm2.1Lbox
Category
allele
Allele of gene
Bcl2
Transgenic Constructs
None
Synonyms
  • IgH-3'E-bcl2
Description
The IgH 3' enhancer (normally located 170 kb from the promoter) with a floxed neo cassette was inserted downstream of the untranslated region. This insertion mimics the t(14;18) chromosomal translocation associated with human follicular B-cell lymphoma. Cre-mediated recombination removed the neo cassette. Protein expression is increased 3.5- to 5.5-fold.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations