Allele/Variant

Tg(tetO-SNCA*A53T)33Vle

Species
Mus musculus
Symbol
Tg(tetO-SNCA*A53T)33Vle
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • tetP-A53Talpha-syn
Description
This transgene consists of the human alpha-synuclein cDNA encoding a mutated protein with an Ala53Thr mutation under the control of the tetracycline responsive promoter. The mutant alpha-synuclein is expressed only in the presence of the tetracycline transactivator (tTA), expressed from a second transgene; administration of doxycycline inhibits tTA binding to tetO, thus suppressing alpha-synuclein expression.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations