Allele/Variant

Tg(tetO-APPSwInd)Dbo

Species
Mus musculus
Symbol
Tg(tetO-APPSwInd)Dbo
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • TetO-hAPP
  • Tg(tetO-APP*Swe*Ind)#Dbo
Description
The mouse amyloid beta (A4) precursor protein (APP) sequence was modified to contain a humanized amyloid-beta (Abeta) domain. This mouse/human chimeric APP (mo/huAPP695 or APP695) was mutated to incorporate the Swedish (KM570/571NL) and Indiana (V617F) APP mutations associated with Alzheimer's disease. This APP695swe/ind sequence was placed downstream of the tetracycline-responsive (TRE or tetO) promoter and mouse prion protein exons 1-2. Lines 18, 102, 107, and 885 were established. When mice are crossed with a line expressing a tTA transgene, these mice show the greatest doxycycline sensitivity for transgene suppression. The pound symbol (#) is used when no line is specified and/or lines are pooled.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
  • tetO
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
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