Version: 8.0.0
Date: Tue Jan 28 2025
Tg(Il9-cre)#Stck
MGI:5296240Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(Il9-cre)#Stck

Species
Mus musculus
Symbol
Tg(Il9-cre)#Stck
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Il9Cre
Description
A targeting construct containing a cre-IRES-mCherry sequence was inserted upstream of the ATG translation initiation site of Il9 via homologous recombination into a BAC clone (RP24-282A18). The recombined BAC was injected into fertilized (CBA x B10)F1 oocytes. Analyses of T cells isolated from crosses to ROSA26-EYFP mice identified only 10% of Il9-producing cells were marked by EYFP. It was discovered that the IRES and mCherry in the construct was disabled because of a premature translational start site in the IRES sequence which possibly diminished activity from the ATG of mCherry sequence.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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