Allele/Variant

H2-Eb1b-tm1a(KOMP)Wtsi

Species
Mus musculus
Symbol
H2-Eb1b-tm1a(KOMP)Wtsi
Category
allele
Allele of gene
H2-Eb1
Transgenic Constructs
None
Synonyms
  • H2-Eb1tm1a(KOMP)Wtsi
Description
The L1L2_Bact_P cassette was inserted at position 34532721 of Chromosome 17 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 34532737. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
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