Version: 8.0.0
Date: Tue Jan 28 2025
Tg(CMV-MYOC*Y437H)#Vcs
MGI:5302242Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(CMV-MYOC*Y437H)#Vcs

Species
Mus musculus
Symbol
Tg(CMV-MYOC*Y437H)#Vcs
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Tg-MYOCY437H
  • Tg(CMV-MYOCY437H)/Vcs
Description
This transgene expresses human myocilin containing the Y437H mutation under the control of the CMV promoter. Expression of the mutant protein is seen in the iridocorneal angle and sclera but is absent in the retina, similarly to endogenous Myoc expression. Mutant protein accumulates in the endoplasmic reticulum.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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