The gingame phenotype was identified among ENU-mutagenized G3 mice in a screen for mutants with susceptibility to dextran sulfate sodium (DSS)-induced colitis. ENU-induced A to T transition at position 416037032 bp in the Genbank genomic region NC_000072.5 on Chr6:41602769-41630722 bp, - strand. The mutation corresponds to nucleotide 1031 in exon 8 of 15 total exons. The mutation results in a valine to glutamic acid substitution at amino acid 306.