Version: 8.0.0
Date: Tue Jan 28 2025
Foxo1tm2.1Dac
MGI:5305499
Allele of Foxo1
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Foxo1tm2.1Dac

Species
Mus musculus
Symbol
Foxo1tm2.1Dac
Category
allele
Allele of gene
Foxo1
Transgenic Constructs
None
Synonyms
  • Foxo1KR
Description
Exon 2 was replaced with a floxed neo cassette and a modified exon 2 with nucleotide substitutions that result in the amino acid substitutions of arginine for lysine at positions 219, 242, 245, 259, 262, 271, 291 (K219R, K242R, K245R, K259R, K262R, K271R, and K291R). These mutations produce a constitutively deacetylated allele. Cre-mediated recombination removed the neo cassette.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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