Version: 8.0.0
Date: Tue Jan 28 2025
Slc26a5tm4(cre/ERT2)Jnz
MGI:5316514
Allele of Slc26a5
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Slc26a5tm4(cre/ERT2)Jnz

Species
Mus musculus
Symbol
Slc26a5tm4(cre/ERT2)Jnz
Category
allele
Allele of gene
Slc26a5
Transgenic Constructs
Synonyms
  • Prestin-CreERT2
Description
A targeting vector was generated using recombineering methods to modify a BAC containing the Slc26a5 (prestin) locus. An IRES-cre/ERT2-frt-neo-frt cassette was inserted after the stop codon in exon 20. The vector was electroporated into TL-1 ES cells to produce knockin mice. When crossed to EGFP reporter mice, cre activity was observed in outer hair cells in the cochlea at P2 with tamoxifen treatment at P0. No reporter signal could be detected in vestibular organs, testis or brain (tissues that express Slc26a5 at low levels.)
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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