Allele/Variant

Tg(NPHS2-Trpc6*E896K)F75aWalz

Species
Mus musculus
Symbol
Tg(NPHS2-Trpc6*E896K)F75aWalz
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Trpc6-HA E896K
Description
The Trpc6-HA wildtype cDNA sequence was made by modifying a Trpc6 cDNA sequence (encoding a 930 amino acid protein) originally isolated from mouse brain tissue by both repairing an A2615G point mutation (D872G) and also by in-frame addition of an influenza virus hemaglutinin epitope (HA-tag) at the 3' end. The cDNA sequence was placed downstream of a 2.5 kbp fragment from the promoter/enhancer region of the human podocin locus (NPHS2) and upstream from a bovine growth hormone polyA sequence. The G2686A nucleotide substitution was introduced to produce the amino acid substitution of lysine for glutamic acid at position 896 (E896K). Lines F73a and F75a were generated.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations