Allele/Variant

Frzbtm1.1Fplu

Species
Mus musculus
Symbol
Frzbtm1.1Fplu
Category
allele
Allele of gene
Frzb
Transgenic Constructs
None
Synonyms
None
Description
Exon 1 was floxed and an FRT flanked neo cassette was inserted downstream of exon 1 via homologous recombination. Cre mediated recombination deleted exon 1 leaving the neo cassette insertion intact. RT-PCR and immunohistochemical analyses confirmed the absence of mRNA and protein expression in cartilage from homozygous mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal bone remodeling
MGI
abnormal bone structure
MGI
abnormal femur morphology
MGI
abnormal sensory neuron innervation pattern
MGI
abnormal skeleton physiologyMGI
abnormal spinal cord dorsal horn morphology
MGI
decreased hematocrit
MGI
increased bone mineral content
MGI
increased bone mineral density
MGI
increased bone strength
MGI
Showing 1 - 10 of 12 rows
per page

Disease Associations