Version: 8.0.0
Date: Tue Jan 28 2025
Lrp2tm3Tew
MGI:5426261
Allele of Lrp2
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Lrp2tm3Tew

Species
Mus musculus
Symbol
Lrp2tm3Tew
Category
allele
Allele of gene
Lrp2
Transgenic Constructs
None
Synonyms
  • MegalinTgICD
Description
Exon 1 and 3.6Kb of intron 1 were replaced by a minigene construct encoding amino acids 4448-4661 of the mouse Lrp2 (megalin) polypeptide (NM_001081088) and stop codon fused to 3 copies of the flag epitope at the amino terminus. A neo resistance cassette immediately follows the megalin intracellular domain (ICD) construct. Western blot analysis confirmed cytosolic expression of the ICD form in kidneys but not the wild-type product.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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