Allele/Variant

Tg(CAG-DMPK*)1323Coop

Species
Mus musculus
Symbol
Tg(CAG-DMPK*)1323Coop
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • EpA960
Description
This transgene contains a ubiquitously expressed pCAGG CMV enhancer/chicken beta-actin promoter, a floxed concatemer of three SV40 polyadenylation sites, and the human DMPK exon 15 containing 960 copies of interrupted CTG repeats (containing CTCGA after every 20 CTG repeats). The SV40 polyadenylation sites prevent expression of RNA from downstream genomic segments, and their removal by Cre-mediated recombination results in transcription and splicing of DMPK exon 15 into the transgene mRNA. Three lines were made, with the 1323 line showing the highest expression of mRNA from the recombined allele.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
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