This transgene consists of a 152 kb bacterial artificial chromosome clone, 189N3, containing the whole mouse Dyrk1a gene with a 6 kb flanking fragment on the 5' side and a 19 kb flanking fragment on the 3' side and retrofitted to containa a PGKneo cassette (189N3 BAC clone from Research Genetics). The clone contains only the Dyrk1a gene and this transgene contains one extra copy of Dyrk1a.