Allele/Variant

Trp53tm1.1Rfo

Species
Mus musculus
Symbol
Trp53tm1.1Rfo
Category
allele
Allele of gene
Trp53
Transgenic Constructs
None
Synonyms
  • p53P275S
Description
A loxP site flanked neomycin resistance gene and STOP cassette was inserted into intron 1. Exon 8 was replaced with a modified exon 8 in which a C-to-T substitution results in the amino acid substitution of proline with serine at position 275 (p.P275S). This mutation corresponds to a proven UVB exposure mutational hostspot at human codon 278. Cre-mediated recombination removed the neo/STOP cassette.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
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