Slc4a4^tm1.1Slin

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Species

Mus musculus

Symbol

Slc4a4^tm1.1Slin

Category

allele

Allele of gene

Slc4a4

Transgenic Constructs

None

Synonyms

• NBC1^W516X

Description

A floxed neo cassette was inserted into intron 10 and a G to A mutation, resulting in a premature stop codon at position 516 (W516X), was inserted into exon 11 via homologous recombination. Cre mediated recombination removed the neo cassette. RT-PCR indicates a significant reduction in expression in kidneys in homozygous and heterozygous mice. Immunofluorescence analysis failed to detect protein expression in kidneys from homozygous mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations