Dnah11^b2b1727Clo

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Species

Mus musculus

Symbol

Dnah11^b2b1727Clo

Category

allele

Allele of gene

Dnah11

Transgenic Constructs

None

Synonyms

• Mickey

Description

This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. The causitive molecular lesion for the cardiovascular phenotypes is a T to C substitution in the +2 position after coding nucleotide 1137 of the cDNA (c.1137+2T>C, NM_010060) in intron 6 of the gene. This changes the splice donor site from G-GT to G-GC (which is assumed to be less efficient).

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations