Version: 8.0.0
Date: Tue Jan 28 2025
Pik3catm1Gilb
MGI:5438138
Allele of Pik3ca
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Pik3catm1Gilb

Species
Mus musculus
Symbol
Pik3catm1Gilb
Category
allele
Allele of gene
Pik3ca
Transgenic Constructs
None
Synonyms
  • Pik3caE545K
  • Pik3caloxE545K
Description
A floxed puro/STOP cassette was inserted upstream of the exon containing the initiation codon. Exon 9 was replaced with one in which nucleotide substitution results in the amino acid substitution of lysine for glutamic acid at position 545 (E545K). Flp-mediated recombination removed the floxed neo cassette inserted into intron 9. Cre-mediated recombination is required to achieve expression of the knock-in allele.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
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