Allele/Variant

Idh1tm2Mak

Species
Mus musculus
Symbol
Idh1tm2Mak
Category
allele
Allele of gene
Idh1
Transgenic Constructs
None
Synonyms
  • Idh1LSL-R132H
  • Idh1LSL
Description
Arginine codon 132 (CGA) in exon 3 was changed to histidine (CAC) (p.R132H) and a loxP site flanked STOP cassette (puromycin resistance gene, splice acceptor sequence and four copies of SV40 poly(A) signal sequence) was inserted into intron 2. This is a knockout allele and only after Cre-mediated removal of the STOP cassette will it express the mutated transcript and peptide.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations