Tyk2^tm3.1Biat

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Species

Mus musculus

Symbol

Tyk2^tm3.1Biat

Category

allele

Allele of gene

Tyk2

Transgenic Constructs

None

Synonyms

• Tyk2^K923E
• Tyk2^{tm3(K923E)Biat}

Description

Exon 20 was replaced with a modified one in which nucleotide substitutions (AAG GCC CTG to GAG GCC CTT) result in the amino acid substitution of glutamic acid for lysine at position 923 (K923E) and introduced a BspTI restriction enzyme site. A floxed neo cassette inserted downstream of exon 21 was removed by cre-mediated recombination. In vitro kinase activity confirmed the absence of activity.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations