Allele/Variant

Eef2tm1.1Lepp

Species
Mus musculus
Symbol
Eef2tm1.1Lepp
Category
allele
Allele of gene
Eef2
Transgenic Constructs
None
Synonyms
  • eEF2G17R
Description
A Gly to Arg point mutation at position 717 in exon 12 and a new SacII site in exon 12 were introduced and a floxed neo cassette were inserted after exon 14 via homologous recombination. Cre mediated recombination removed the neo cassette. The point mutation eliminates the diphthamide modification on the protein but leaves the diphthamide biosynthesis machinery intact.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations