Version: 8.0.0Date: Tue Jan 28 2025
Allele/Variant
Syktm2.1(ZAP70)Fkfr
- Species
- Mus musculus
- Symbol
- Syktm2.1(ZAP70)Fkfr
- Category
- allele
- Allele of gene
- Syk
- Transgenic Constructs
- Synonyms
- Sykki
- SykZap-70 delta
- Description
- The coding sequence in exon 2 was replaced with a human cDNA for Zap70 and an FRT-flanked neo cassette. Flp-mediated recombination removed the neo cassette. Western blot analysis confirmed the absence of endogenous protein expression and expression of the human cDNA.
- Additional Information
- Literature
Transgenic Constructs
This allele contains 1 transgenic construct- Symbol
- Expressed Components
- Knock-down Targets
- None
- Regulatory Regions
- None
Phenotypes
Phenotype | Annotation details | Source | References |
|---|---|---|---|
| abnormal B cell physiology | MGI | ||
| abnormal neutrophil physiology | MGI | ||
| abnormal renal glomerular capsule morphology | MGI | ||
| abnormal renal glomerulus basement membrane morphology | MGI | ||
| arrested B cell differentiation | MGI | ||
| decreased B cell number | MGI | ||
| decreased blood urea nitrogen level | MGI | ||
| decreased bone marrow cell number | MGI | ||
| decreased circulating creatinine level | MGI | ||
| decreased DN1 thymic pro-T cell number | MGI |