Setd6^{tm1.1(KOMP)Mbp}

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Species

Mus musculus

Symbol

Setd6^{tm1.1(KOMP)Mbp}

Category

allele

Allele of gene

Setd6

Transgenic Constructs

None

Synonyms

None

Description

The insertion of the L1L2_Bact_P cassette created a deletion of size 2021 starting at position 96442973 and ending at position 96444994 of Chromosome 8 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Subsequent cre expression excised this neomycin resistance cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations