Allele/Variant

Tg(Th-Twnk*,-EGFP)2Gcor

Species
Mus musculus
Symbol
Tg(Th-Twnk*,-EGFP)2Gcor
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Tg(Th-Peo1*,-EGFP)2Gcor
Description
The transgene contains 9.0 kb of upstream sequence from the rat tyrosine hydroxylase gene that drives dopamine neuron-specific expression of the mouse gene with a silent point mutation at position 1077 (c.1077C->G). This mutation forms a restriction enzyme site and allows for the insertion of 39 nucleotides that produces a duplication of amino acids 353 to 365. An IRES-EGFP and polyadenylation sequence follow the altered mouse gene. Four of six lines have higher EGFP expression than wild-type mice. Lines 1, 2, 3 and 4 contain 181, 227, 141, 97, 42 and 6 copies of the transgene, respectively.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
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