Allele/Variant

Gt(ROSA)26Sortm2Jake

Species
Mus musculus
Symbol
Gt(ROSA)26Sortm2Jake
Category
allele
Allele of gene
Gt(ROSA)26Sor
Transgenic Constructs
None
Synonyms
  • ROSA-MSP
Description
A cassette, consisting of the CAG (CMV-chicken beta actin) promoter, a splice acceptor site, a floxed pgk-neo stop construct, and the mouse Mir21 sponge sequence, was inserted via homologous recombination. The sponge sequence contained seven Mir21 binding sites (sequence UCAACAUCAGGACAUAAGCUA). This sequence acts as a competitive inhibitor for the microRNA.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal astrocyte morphologyMGI
abnormal astrocyte physiologyMGI
abnormal response to injuryMGI
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Disease Associations

No data available